Percutaneous toxicity of ethylene glycol and 1,2 propylene glycol in rats

Forty albino rats were divided into four equal groups. The three test groups were applied percutaneously with 1000 mg /kg of ethylene glycol, 1, 2-propylene glycol and a mixture of equal amounts of both ethers respectively, while the fourth group served as a control. The application was done 6 days / week for 8 weeks. Results of the ethylene glycol and combined [ethylene and propylene glycols] groups revealed depression of bone marrow cellularity with significant changes in the Hb concentration and the blood cell counts. Histopathological findings of liver, lungs and kidneys showed marked evidences of toxicity whereas the testes were slightly affected and the application site of the skin was found normal. Minimal changes were observed in the propylene glycol group

Biochemical and histopathological changes as markers of alcoholism in atbino rats

Fourty mature albino rats of buth sexes were divided into four equal groups. Three groups received doses equivalent to 1/20, 1/10 and 1/5 L D50 of ethanol, six days/week orally for eight weeks. The remaining group served as a control. Serum and vitreous levels of Na, K, uric acid, ALT, AST and GGT were measured. Most of the obtained results were significantly different from those of the control group in such a way that would help in detecting alcohol abuse especially the GGT levels. Histopathological findings in the internal organs of rats [liver, kidneys, lungs, spleen and testes] revealed changes of variable degree of severity, but are not pathognomonic for alcohol abuse